Igennus Super B-Complex Methylated B Vitamins, Sustained Release, Clean Label, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, Vegan, Lab Verified, 60 Small Tablets

Excellent product. No after taste and no upset stomach. Highly recommend.

After years of taking regular B vitamin supplements with little to no effect, I finally discovered—through genetic testing with my doctor—that I have a gene mutation (MTHFR) that affects my body’s ability to absorb and convert standard B vitamins. That explained the constant fatigue, brain fog, and low mood despite supplementing consistently.These methylated B vitamins have been a game-changer. Because they're already in their active, bioavailable form (like methylcobalamin and methylfolate), my body can actually absorb and use them properly. Since switching to this formula, I’ve experienced a noticeable boost in energy, better mental clarity, and a more stable, uplifted mood.If you’ve been taking regular B vitamins without results and suspect absorption issues or have been diagnosed with an MTHFR mutation, I highly recommend giving these a try. They've made a real difference in my daily quality of life.

I am compound heterozygous (MTHFR ). Which is normally not a huge deal, but I also have a history of stroke and autoimmune activity as well as activated Epstein-Barr virus. It becomes a little more important to get the right B complex.If you are experiencing non-stop fatigue and cannot figure out why definitely ask your doctor about Epstein-Barr virus and getting tested along with having a test for MTHFR. I exhausted the other options and finally may have my answer. It seems that Covid may have reactivated my Epstein-Barr virus, which should remain dormant after having mono when I was a teenager 30 years ago.I was going to go with a different company until I realized that they had a different form of B6 then was ideal for someone with MTHFR.This brand has the form I wanted. Here is why:Confirm B6 FormIf the label just says “Pyridoxine” or “Vitamin B6” without specifying P-5-P, then it’s likely the inactive form (pyridoxine HCl).• Some people with MTHFR (or impaired liver detox) don’t convert pyridoxine well.• Look for P-5-P (pyridoxal-5-phosphate) — it’s gentler, active, and more effective for reducing homocysteine.Watch for Niacin Form & Dose• If it contains nicotinic acid, high doses can use up methyl groups and cause “niacin flush”• If it’s niacinamide or in small amounts, it’s usually fine• You don’t have to avoid it — just good to be aware, especially if you ever feel flushed or tired after taking it👀 this brand has the no flush niacin😁If you are positive for MTHFR be sure to research these things. I was pleased to find that this is a good choice.I have just started taking it for a couple of weeks. It is yellow of course I do not chew it so I do not know what the taste is, but it is fairly quick and I just take two at a time. It does say you can take them at two separate times. Quick and easy great choices.Using the proper forms of B vitamins—especially 5-MTHF (methylfolate)—is essential for people with MTHFR mutations because their bodies can’t efficiently convert synthetic folic acid into the active form needed for methylation. Taking methylated forms (like 5-MTHF and methylcobalamin) bypasses the genetic bottleneck, allowing the body to process nutrients, detoxify properly, and regulate homocysteine levels more effectively.📝I will update in a couple of months to see what results I get.

I like this product!! Seems to work well!!

Why did you pick this product vs others?:Great brand. Methylated b complex is great for my energy and easier for me to metabolize

Worked as described. The methylated version is the active form of the B vitamin, so it works better for me than normal B vitamin complexes. It is for people with certain gene mutations who cannot process the unmethylated version of the active form of a B vitamin. This is why I tried it. Fairly small; seems to be good quality. I would recommend sucking on it, but it didn't taste bad; I just took it with water. I didn't let it dissolve.

I'm pretty sure this is the best B-vitamin I have ever taken. My feet started itching- did you know that's a sign of a B-12 deficiency? Anyway, I've always known I need the methyl forms of B-12 and B-6 and I wanted a sublingual, but I liked the reviews of this one so decided to give it a shot. I actually take it like a sublingual (it's gross, though) and let me tell you, the effect is immediate! I can feel my eyes getting clearer and a boost in my energy and mood. It's incredible.